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Evidence is increasing that addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This the main problem regulates reward responses in getting food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both whenever they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight loss and the people that go through it you should err to the side of caution and let the FDA do its job and demand some research be done in order that the public recognizes the side effects and dangers of the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on his or her medications.

Researchers found that participants taking this drug for the year, dropped a few pounds within one month and have kept the body weight off throughout the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which might be made up of multiple active ingredient, that might make them far better and safer.

Combo-pilling will be the newest fad or in addition to this the newest into the future under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that at the time of right now there aren't long term prescription diet pills that have been authorized by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure levels and heartbeat, and mustn't be used in people with a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must stop used in patients with uncontrolled high blood pressure levels, in addition to by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.


"This is the first drug I'm alert to that targets the appetite and reward centres inside brain," he explained.